CCL21 and amyotrophic lateral sclerosis: Reactome underlined the role of miRNAs in LEVs (Table S2): (1) from ALS patients in intracellular signaling by second messengers (DAG, cAMP, cGMP, IP3, Ca2+ and phosphatidylinositols), signaling by TGF-beta family members, MyD88 cascade initiated on plasma membrane and metabolism of lipids; (2) from PD patients in intracellular signaling by second messengers, SLC-mediated transmembrane transport (solute carrier superfamily), some of which mediate neurotransmitter uptake in the CNS and peripheral nervous system (PNS) and metabolism of lipids.