In SEVS from PD patients Reactome analysis identified signaling by TGF-beta family members, SLC-mediated transmembrane transport (regulation of GRIA1, subunit of Glutamate receptors, by miR-132-3p, Metabolism of lipids, MyD88 cascade initiated on plasma membrane (involvement of JAG1 and TNF regulated by miR-34-Sup IPA), while GeneOntology BP fibroblast migration, mRNA polyadenylation and positive regulation of gene silencing by miRNA (Figure 4c). This evidence concerns the gene MYD88 and Parkinson disease.