The most important genetic variants are the rs58542926 C > T located in the transmembrane 6 superfamily member 2 (TM6SF2) gene and the rs641738 C > T located in the membrane-bound O-acyl-transferase domain-containing 7 (MBOAT7) gene, which favor hepatic fat accumulation in intracellular lipid droplets via different mechanisms, increasing the susceptibility to inflammation, NASH and fibrosis [67]. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatohepatitis.