WWTR1 and pulmonary arterial hypertension: In the liver, YAP and TAZ stimulate glutamine synthetase to produce glutamine in order to favor the de novo nucleotide synthesis pathway [138], whereas in pulmonary arterial hypertension, vascular stiffness activates YAP/TAZ, which in turn promote not only glycolysis, but also glutaminolysis in pulmonary vascular endothelial cells, through the modulation of the glutaminase enzyme [140].