Several studies demonstrate a bidirectional regulation: on the one hand, YAP increases the activity of mTOR through the suppression of phosphatase and tensin homolog (PTEN) via microRNA [143], and on the other both mTOR Complexes mTORC1 and mTORC2 positively regulate YAP in perivascular epithelioid cell tumors and glioblastomas [36,144,145]. Here, PTEN is linked to glioblastoma.