In conclusion, according to our experimental results, Schisandrol A inhibited the expression of MMP3, MMP13, and COX-2 factors known to cause cartilage destruction, by inhibiting the NF-κB signaling pathway (Figure 4D), and it suppressed cartilage destruction in a mouse model of degenerative arthritis (DMM model). Here, PTGS2 is linked to osteoarthritis.