The reduction of Ang II levels with ACE inhibitors has reported similar improvement in endothelial function in different vascular vessels, including aorta, coronary and epineural arterioles in models of obesity but also in obese patients in which the treatment with ACE inhibitors was able to ameliorate endothelial function in coronary arterioles from obese patients undergoing heart surgery [139,140,141,142]. Here, AGT is linked to obesity due to melanocortin 4 receptor deficiency.