In this same line, it has been demonstrated that neutrophils stimulated with albumin obtained from patients with high levels of HNA-1 and HNA-2 show an increase in gene expression related to ROS production, pro-inflammatory cytokines, and high levels of neutrophil gelatinase-associated lipocalin [78], a glycoprotein which is considered a biomarker for acute and CKD [79,80] and for cardiovascular disease [81,82]. This evidence concerns the gene ALB and chronic kidney disease.