ALB and chronic kidney disease: Although there is not enough data showing a difference between HNA-1 and HNA-2 for CKD risk in obese patients, the literature available suggests that albumin oxidation reflects a state of pro-inflammatory renal injury that may favor CKD progression (Figure 3), in particular, considering that aging patients, a population that present a higher risk for CKD, also present higher HNA-1 levels.