While HNSCC with a low CD8-positive T cell inflamed phenotype were enriched for β-catenin and Hedgehog pathways, NSD1 mutations and EGFR amplifications, a high CD8-positive T cell inflamed phenotype was associated with MAPK/ERK and JAK/STAT pathways, CASP8 mutations and CD274 amplifications [66]. This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.