Messinaet al. [96] implemented a 12-chemokine gene signature, which was related with induced CD8-positive T cell infiltration and overall survival in melanoma metastases, to analyze multi-omics data of two cohorts with primary HNSCC, TCGA-HNSC and the Chicago Head and Neck Genomics (CHGC) cohort [66]. Here, CD8A is linked to head and neck squamous cell carcinoma.