BCL2 and cancer: In addition, fully functional in vitro Bcl-2 protein (and its constructs for specific sub-functions) is a potentially powerful drug target for anti-cancer drug discovery; an application we demonstrated by screening against fluorinated chemical libraries using 19F and 1H-15N TROSY NMR to obtain the potential hits from diverse chemical libraries which can be further optimized with NMR SAR (Structure-activity relationships) to obtain promising anti-cancer drug candidates.