Indeed, when ROS complex was integrated with anti-PD-1 and anti-CD47 mAbs, under the rationale that blocking CD47 will activate phagocytic cells to phagocytize cancer cells and promote antigen presentation [86], melanoma growth was reduced in mice receiving aPD-1@aCD47 complex when compared to free antibody treated and untreated mice. Here, CD47 is linked to cancer.