In this respect, the efficacy, i.e., an improved clinical outcome, a lower degree of organ failure, decreased PAI-1 levels, and ventilator free days, as well as the safety of a small molecule PAI-1 inhibitor, TM5614, are currently investigated in a phase 1/2 clinical trial for high-risk patients hospitalized with severe COVID-19 (ClinicalTrials.gov: NCT04634799). Here, SERPINE1 is linked to COVID-19.