Interestingly, ample evidence has been provided for a paradoxical pro-tumorigenic function of PAI-1, being both pro-angiogenic [93] and anti-apoptotic [94], documented to be dependent on the stage of cancer progression, the cell type, the source (i.e., host or tumor) and on the relative concentration of PAI-1 [93,95,96,97,98]. The gene discussed is SERPINE1; the disease is neoplasm.