CASP8 and non-small cell lung carcinoma: The authors showed that the combination of three polymorphisms in the CASP-8 gene, matrix metalloproteinase-1, selenium and S1 protein, and interleukin-10, was associated with an approximately twofold-higher risk of NSCLC (OR = 2.06, 95% CI: 1.19–3.47), while in people with four genotypes, the risk was estimated to be 4.62 times higher (OR = 4.62, 95% CI: 1.69–12.63) [25].