Given that DUSP1 impaired the activity of JNK and ERK (Figure 2a), and that the individual inhibition of these MAPKs downregulated Snail expression (Figure 2b), as well as cell migration and invasion (Figure 3), we further studied whether these MAPKs cooperated in the regulation of these events in our prostate cancer cells. The gene discussed is MAPK8; the disease is prostate carcinoma.