Collectively, all the results in human prostate samples reveal the existence of an inverse correlation between DUSP1 expression and the levels of Snail and activated JNK and ERK (negative correlation at Pearson ́s test, p < 0.001), supporting our experiments in prostate cancer cells which demonstrate that DUSP1 downregulates Snail expression. Here, MAPK8 is linked to Familial prostate cancer.