Rheumatoid arthritis (RA) [22], inflammatory bowel disease (IBD) [23,24,25], psoriatic arthritis (PsA), psoriasis (PS) [26], and noninfectious uveitis (NIU) are induced by the abnormal secretion of TNF-α; thus, TNF-α can be classified as a key factor in the pathological development. The gene discussed is TNF; the disease is inflammatory bowel disease.