Implantation of glioma cells isolated from resected tumor tissue into the abdomen of glioma patients treated with drug-inhibiting insulin-like growth factor receptor-1 (IGF-1) induced apoptosis in implanted cells, and this was followed by exosome release from these cells that stimulated the immune system to induce a T-cell mediating antitumor response (NCT01550523). Here, IGF1R is linked to central nervous system cancer.