STAT3 and neoplasm: An exosome preparation of JSI-124 (a STAT3 inhibitor) effectively reduced tumor volume in a murine model of GBM [170,202,203], and notably, exosomes containing 5-fluorocytidine (a prodrug) facilitated its conversion to 5-fluorouracil and 5-fluoro-deoxyuridine and resulted in tumor cell apoptosis in an orthotopic model of schwannoma [175,204].