ANXA1 and neoplasm: In addition to autocrine action, Annexin A1 can signal in a paracrine or juxtacrine mode to FPRs on tumor-infiltrating leukocytes, such as dendritic cells [22], tumor-associated macrophages [23], neutrophils [24], natural killer (NK) cells [25], or T cells [25,26], which could potentially influence immune cell function to favor tumor growth.