ANXA1 and neoplasm: Moreover, the reduced tumorigenicity of Annexin-A1-depleted cells was associated with almost complete loss of a discrete CD24+/Sca1− cell compartment containing putative tumor initiating cells (TICs) that display an epithelial phenotype, and concomitant acquisition of a CD24−/Sca1+ population with a mesenchymal stem cell-like phenotype.