In this study, we analyzed the distribution of three neurotrophins (NGF, BDNF, and NT-3) and four neurotrophin receptors (TrkA, TrkB, TrkC, and p75NTR) in brain samples sourced from two different models of scrapie: sheep as the natural host, and Tg338 transgenic mice, which express the ovine PrPC, as an experimental model. Here, PRNP is linked to scrapie.