Correlation coefficients of these three parameters with glial p75NTR labeling were computed and significant results were found in each case (Figure 6), indicating that the accumulation of the causal agent (PrPSc) and its related neuropathological alterations (spongiosis and gliosis) are linked to the presence of p75NTR-positive glial cells. Here, NGFR is linked to Gliosis.