When the analysis was adjusted according to Child class as surrogate marker of clinically significant portal hypertension, the difference of VWF levels between HCC and non-HCC patients was significant in Child A [270% (170–417) vs. 206% (138–289), p = 0.01] but not in Child B [423% (282–501) vs. 315% (248–401), p = 0.1] and Child C [436% (258–551) vs. 322% (212–450); p = 0.3] class. This evidence concerns the gene VWF and portal hypertension.