Among patients with HCC, platelet aggregation was relatively higher in those with multinodular vs. those with a single nodule [ADP-induced: 54 AUC (36–68) vs. 40 AUC (28–56), p = 0.07; ASPI-induced: 51 AUC (37–69) vs. 36 AUC (21–46), p = 0.006; and TRAP-induced: 81 AUC (69–106) vs. 90 AUC (65–124), p = 0.3)], whereas no difference was found when the analysis was performed according to total tumor volume or alpha-fetoprotein level. The gene discussed is AFP; the disease is hepatocellular carcinoma.