TGFB1 and neoplasm: Possible mechanisms in FSD are as follows: (i) impaired epidermal LC network maintenance compromises tumor surveillance [102], promotes KC proliferation [80,81] and gives rise to squamous epitheliomas [103]; (ii) impaired Treg effector function augments tumoricidal activity [11]; and (iii) impairment of the autocrine or paracrine loop of TGF-β signaling inhibits EMT or immunoevasion, respectively [31,82,96,101] (Figure 1).