In addition, they evidenced as an independent positive prognostic factor a long interval between the primary diagnosis and the detection of breast cancer liver metastasis (BCLM) more than 1 year, liver-limited disease (with the exception of isolated pulmonary and bone metastasis), response to preoperative systemic therapy before hepatic surgery, and the BCLM expression of estrogen receptor (ER) and progesterone receptor (PgR). Here, ESR1 is linked to bone metastasis.