INS and Glucose intolerance: The deleterious effects of mTOR inhibitors on glucose metabolism might be induced by an increased insulin resistance secondary to a reduction of the insulin signaling pathway within the cells and/or by a reduction of insulin secretion via a direct effect on pancreatic β-cells [40,41], but probably the main mechanism rests on the induction of gluconeogenic pathway in the liver, which potentiates glucose intolerance [42].