VWM is a neurological disease caused by mutations in the eukaryotic translation initiation factor 2B (EIF2B) that produce bi-allelic pathogenic variants in one of five genes: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5 [4]. Here, EIF2B1 is linked to leukoencephalopathy with vanishing white matter.