VWF and von Willebrand disease (hereditary or acquired): Thus, global VWF-dependent primary hemostasis is screened, and the pathological prolongation of the closure time may be indicative of a moderate-to-severe VWD or platelet function defects [47,53,54] but not for mild platelet disorders (e.g., storage pool defects and primary secretion defects) due to the lack of specificity and sensitivity [55,56].