DAPK1 and glioblastoma: In U-251 malignant glioblastoma cells, CUR mediated G2/M cell cycle arrest was explained by the elevation of the protein kinase 1 (DAPK1) level, which suggests that inhibiting DAPK1 via CUR stimulates cell arrest and also causes NF-κB and STAT3 suppression and caspase-3 activation [314].