Moreover, the light A2A expression generally observed in the entopeduncular nucleus of Tor1a+/+ mice [33] and its significant decrease in Tor1a+/− mice, detected with different techniques, cannot be considered functionally irrelevant, and this suggests that A2A receptors in the direct pathway could also be involved in basal ganglia function and in dystonia pathophysiology. This evidence concerns the gene TOR1A and Dystonia.