PDE10A and early-onset generalized limb-onset dystonia: In a previous work, we reported that PDE10A-dependent cAMP hydrolyzing activity as well as total PDE activity are unaffected in the striatum of a mutant mouse model of DYT1 dystonia, wherein at the same time the PDE10A-dependent cAMP hydrolyzing activity was increased in the globus pallidus and decreased in the entopeduncular nucleus [37].