The cross-talk between PPARδ and TRPV1 also emerged in a study carried out by Gao et al. [147] where the administration of chronic dietary capsaicin attenuates cardiac hypertrophy and fibrosis associated to with a high-salt diet through the TRPV1-mediated up-regulation of PPARδ expression in cardiomyocytes. The gene discussed is PPARD; the disease is cardiac hypertrophy.