PPARA and obesity due to melanocortin 4 receptor deficiency: In this context, it has been recently demonstrated that daily ingestion of Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut, reduces the risk of developing diet-induced obesity and concomitantly insulin resistance by increasing the plasma levels of mono-palmitoyl-glycerol, an endocannabinoid lipid acting as PPARα agonist [148].