In addition, a link between ATP13A2 and αsyn in the context of PD pathology was supported by the finding that αsyn overexpression-induced toxicity in yeast could be rescued by co-expression of the yeast ATP13A2 ortholog YPK9, and dopaminergic neuron loss in Caenorhabditis elegans was antagonized by ATP13A2 [28]. The gene discussed is ATP13A2; the disease is Parkinson disease.