Different mutations in the ATP13A2 gene have been shown to be involved in different neurodegenerative diseases including Kufor–Rakeb syndrome, early-onset PD, hereditary spastic paraplegia, neuroid ceroid lipofuscinosis, and amyotrophic lateral sclerosis [16,17,18,19,20]. The gene discussed is ATP13A2; the disease is parkinsonism due to ATP13A2 deficiency.