Notably, by examining The Cancer Genome Atlas (TCGA) and Genomic Data Commons (GDC) datasets concerning MPM patients analyzed and eventual Nrf2, Ref-1, and FOXM1 prognostic values, the results showed, out of 87 MPM samples analyzed, that none of the three proposed transcription factors have been analyzed up to now, although in lung cancer they have already been identified and quite associated with a worse prognosis. The gene discussed is APEX1; the disease is lung cancer.