In the context of MPM therefore, in which there is a prolonged exposure to asbestos related oxidative stress induction, other studies have shown that an aberrant increase in the antioxidant systems, mediated by Nrf2 overexpression, may have a role in promoting tumorigenicity and chemoresistance [49], supporting the importance of this factor as a possible pharmacological target in many types of cancer [19]. Here, NFE2L2 is linked to cancer.