ARNT2 disease-associated missense variants are linked to large intestine cancer (A28V, R47C, R240K, P579S, and T602M), skin cancer (S458L and P529S), CNS cancer (Y430N), lung cancer (A25T and V683L), liver cancer (D191G and G710A), hematopoietic and lymphoid tissue cancer (H543R), pancreas cancer (P269S) and stomach cancer (G31R) (Supplementary Materials). Here, ARNT2 is linked to skin neoplasm.