According to the HuVarBase, SIM2 missense mutations are linked mainly to lung cancer (S343Y, S355F, P385H, T646P, and Q469P), skin cancer (P57S, M164I, E339K, E345K, M377I, P448S, D450N, and F454S), liver cancer (F56L, A70T, G174S, and F394S), and large intestine cancer (A63V, A169V, D202N, and T433M). Here, SIM2 is linked to colorectal cancer.