The other reported cancers associated with the NPAS4 mutations are upper aerodigestive tract (S453C and Q469H), breast (R200H and E628G), kidney (R595W), stomach (T708M), endometrium (P597S), thyroid (S493L), pancreas (R634H), cervix (Q629H), bone (E724K), and CNS (T587M) (Supplementary Materials). Here, NPAS4 is linked to cancer.