It has been demonstrated that simultaneous 4′-CIDzp treatment led to the reduction in myocardial damage, which was particularly determined by less alteration of certain biochemical markers, i.e., decreased levels of hs cTnT, TNF-α, Hcy, UREA, and CREA, reduced oxidative stress markers SOD and GPx, and improved grading in the histochemical analysis (reduced MI size). The gene discussed is TNNT2; the disease is myocardial infarction.