It was detected that LCN2, alongside several other genes that encode secreted and membrane-bound proteins (e.g., AFP, Glypican-3, GPC3, Immunoglobulin superfamily member 1, IGSF1, Prostate-derived Ste20-like kinase, PSK-1), is overexpressed at the HCC site. The gene discussed is IGSF1; the disease is hepatocellular carcinoma.