At the outset of this study, we planned the single and combined doses based on the existing ischemia literature, which shows an inverted U-shaped dose response curve with CBD (effective doses 1.0 and 3.0 mg/kg IP, ineffective doses 0.1 and 10 mg/kg IP), and significant dose effects of BCP starting at 72 mg/kg but absent at lower doses. Here, OPN1MW is linked to ischemia.