Interestingly, systemic administration of trehalose stimulated macrophage autophagy in vivo and decreased atherosclerosis in Apoe−/− mice, but not in mice with myeloid-specific deletion of Atg5, pinning the relevance of macrophage autophagy on the beneficial effects of trehalose on atheroprogression [124]. The gene discussed is ATG5; the disease is atherosclerosis.