Multiple genes with pro-tumorigenic functions were found to be enriched in MCs isolated from tumor regions, including ARG2 [25], ANXA2 [26], metallothioneins (MT1X and MT2A) [27], and TIMP1 [28], which are associated with processes such as tumor growth and differentiation, angiogenesis, metastasis, ECM remodeling, and immune escape (Figure 1f; red bar). This evidence concerns the gene ANXA2 and neoplasm.