SIRPA and Miyoshi myopathy: The immune checkpoint CD47, also known as the “do not eat me” signal, was found overexpressed in MM cells and positively correlated with the stage of disease [95] TTI-622 (SIRPα-IgG4 Fc), is a soluble recombinant fusion protein created by directly linking the sequences encoding the N-terminal CD47 binding domain of SIRPα with the Fc domain of human immunoglobulin (IgG4) [95].