The normalized mRNA expression of general CAF markers, including FAP, ACTA2, MFAP5, COL11A1, VIM, PDGFRA, PDGFRB, and POSTN, were compared between 44 normal samples and 522 HNSCC tissues to identify the CAF markers upregulated in HNSCC. This evidence concerns the gene FAP and head and neck squamous cell carcinoma.