BCOR and BCORL1 proteins function as components of PRC1.1, a noncanonical PRC1, and are frequent targets of somatic mutations in AML, sAML, MDS, and chronic myelomonocytic leukemia (CMML) [6,7,8,9,10,89,90]. The gene discussed is BCOR; the disease is chronic myelomonocytic leukemia.