In the background of STAG2 absence, additional STAG1 loss abrogated hematopoiesis, consistent with the reported synthetic lethality between STAG1 and STAG2 in leukemia cell lines and the redundancy in STAG1 and STAG2 function in chromatid segregation [53,56,57]. This evidence concerns the gene STAG2 and leukemia.