A recent report also demonstrated that SRSF2 and the isocitrate dehydrogenase gene, IDH2, mutations frequently co-exist in human AML cases, and that co-expression of mutant SRSF2 and IDH2 caused lethal MDS/MPN-like diseases with myelodysplasia and proliferative features in mice, possibly through the synergistic effects of these mutations on the epigenome and RNA splicing [39]. Here, IDH2 is linked to myeloproliferative disorder.