SF mutations lead to mis-splicing of key hematopoietic regulators, such as EZH2 and INTS3 in SRSF2-mutated MDS and ERFE, BRD9, and SF3B1 in SF3B1-mutated MDS, which may partially explain the disease phenotypes caused by SF mutations [13,37,38,39,40]. The gene discussed is EZH2; the disease is myelodysplastic syndrome.