Indeed, considered separately, the combination of the three targets CEACAM5, ITGA6 and MACC1 selected to predict AA provided 75% and 79% sensitivity (for 95% specificity) for AA and CRC, respectively and the two targets S100A4 and PTGS2 selected to improve CRC detection provided 29% and 80% sensitivity (for 95% specificity) for AA and CRC prediction, respectively, suggesting that using distinct repertoires of targets for AA and CRC could be used to improve patient stratification for colonoscopy. This evidence concerns the gene S100A4 and colorectal carcinoma.