DHFR and cancer: On the other hand, histamine can influence cell survival and cell proliferation pathways by way of key elements such as mTOR, HIF1A, SMS, and VHL, together with elements of cancer progression hallmarks—ANK1, involved in cytoskeleton remodelling, DHFR in genome methylation, NEIL1 in genome edition, APBB1 and VHL in chromatin covalent modification, and the remarkable role of HIF1A as coordinator of different cancer hallmarks [129].