LRP6 and neoplasm: Among the membrane proteins detected at modified levels were TYRO3, a member of the receptor tyrosine kinase family [75] involved in macrophage dependent efferocytosis and acquisition of pro-tumour phenotype [76], LRP-6, a low-density lipoprotein-related co-receptor that signals via Wnt/β-catenin [77] known to influence macrophage differentiation, migration and function [78].