In LLCM grown BMDMs cultured at 21% O2, there was a general trend of ascorbate-mediated reduction in both gene expression and secretion of pro-tumour proteins, such as the immunosuppressive and anti-inflammatory cytokines IL-10 [55] (qPCR and antibody array) and TGF-β (qPCR and ELISA), as well as the pro-angiogenic factor VEGF-A [55] (qPCR, antibody array and ELISA). The gene discussed is VEGFA; the disease is neoplasm.