AFP and hepatocellular carcinoma: Consistently, AFP showed an AUC value of 0.710, 95% CI 0.634–0.778 (p < 0.001) for the discrimination between cirrhosis and HCC, while serum ERBB3 was not able to discriminate between the two groups of patients (AUC = 0.500, 95% CI 0.421–0.579, p = 0.994) (Figure 1C).