In patients with HCC, serum ERBB3 values were moderately correlated to ALT (rs = 0.204, 95% CI 0.030–0.328, p = 0.007), to AST (rs = 0.229, 95% CI 0.053–0.352, p = 0.002), and to AFP (rs = 0.160, 95% CI 0.015–0.304, p = 0.034). This evidence concerns the gene ERBB3 and hepatocellular carcinoma.