CALR and Decreased total leukocyte count: Moreover, the prognostic value of MSG biopsy has been thoroughly analyzed: higher FS values correlate with specific extra-glandular (Raynaud’s phenomenon, vasculitis, lymph node or spleen enlargement) and laboratory (leukopenia, anti-SSA/SSB and RF positivity) features and with the risk of NHL development [16,81,89].