Many authors have analyzed the connection between SGUS features and patient’s serology (presence of ANA, anti-Ro/SSA and/or anti-La/SSB antibody, RF, CD4+ lymphopenia and reduced number of memory B cells, thrombocytopenia and C4 complements levels), clinical features (lower salivary flow rate, SG swelling, skin vasculitis, an ESSDAI value > 5), and histological findings (presence of GC-like structures in MSG biopsy), many of them being well known lymphoma risk markers, as previously described [24,40,41,42,43]. The gene discussed is SSB; the disease is Thrombocytopenia.