These include: (i) knockdown of ARF1 does not significantly inhibit infection by enteroviruses [232,267,270], and (ii) overexpression of a constitutively active mutant of ARF1 (Q71L-ARF1), when expressed alone or when co-expressed with other constitutively active ARF mutants (ARF3, ARF4 or ARF5), does not rescue enterovirus replication from BFA-inhibition [266,267,271]. The gene discussed is ARF1; the disease is infection.