Besides experimental fibrosis induction in vivo with, e.g., bleomycin or irradiation [3] in a “multiple-hit” model [51,52], ex vivo culture of PLK2 lung tissue and subsequent pharmacological interventions [55] could be feasible approaches towards the development of cost-and time-effective pulmonary fibrosis models and anti-fibrotic drug screening platforms. Here, PLK2 is linked to pulmonary fibrosis.