High levels of BCL-2 expression, comparable to that observed in t(14;18)-containing haematological malignancies, is also seen in FL [23], CLL [24,25], DLBCL [26], multiple myeloma (MM) [27] and mantle cell lymphoma (MCL) [28] despite the absence of the t(14;18) translocation. This evidence concerns the gene BCL2 and AL amyloidosis.