BCL2 and neoplasm: The slow progression to tumour manifestation in the Eμ-BCL-2 mice and the existence of the t(14;18) translocation in healthy individuals, strongly suggest that the overexpression of BCL-2 as a consequence of this genetic aberration can occur beyond the context of malignancy and/or hyperplasia and likely precedes other key oncogenic steps (such as secondary genetic aberrations) required for full neoplastic transformation.