These include microRNA deregulation, where mir-29b downregulation leads to increased MCL-1 expression in CLL and cholangiocarcinoma [31,56] or upregulation of MCL-1 via deregulated external stimuli such as through vascular endothelial growth factor (VEGF) or Interleukin-6 signalling in multiple myeloma and cholangiocarcinoma [57,58]. Here, MCL1 is linked to B-cell chronic lymphocytic leukemia.