Concerning the role of MALAT1 in the regulation of the ERK/MAPK pathway, Chen et al. using in vitro differentiation of neuroblastoma-derived Neuro-2a (N2a) cell as a model for the investigation of lncRNAs in neurogenesis, identified that MALAT1 was one of the most significantly upregulated lncRNAs during N2a cell differentiation. The gene discussed is MALAT1; the disease is neuroblastoma.