Low-immunogenic tumor is characterized by the absence of cells involved in non-specific (NK cells, macrophages, neutrophils) and specific (effector T lymphocytes, T regulatory cells, T helper cells) immune responses and a lack of chemotactic factors and pro-inflammatory cytokines in the tumor microenvironment (IL-6, IL-2, IL-12, TNF-alpha). This evidence concerns the gene TNF and neoplasm.