In experiments in mice, it was observed that the dose of 8 Gy ionizing radiation per tumor area in combination with the administration of anti-CTLA-4 antibody resulted in disease remission, tumor size reduction, as well as an abscopal effect on the metastases located outside the radiation area, which contributed to the cure of mice and inhibited the development of residual disease. Here, CTLA4 is linked to neoplasm.