The anticancer immune response of ICD is contributed by the release of damage-associated molecular pattern molecules (DAMPs) by dying cancer cells and stressed cancer cells, such as high-mobility group box 1 (HMGB1), heat shock protein 70 (Hsp70), ATP, annexin A1 (ANXA1), and calreticulin (CRT). This evidence concerns the gene HMGB1 and cancer.