Weide et al. [28] reported the efficiency of protamine/mRNA complex by experimental analysis of intradermally-inoculated protamine/mRNAs complex that encodes for a variety of enzymes, such as Tyrosinase (an enzyme that helps to catalyze melanin formation), Melan-A (a melanoma antigen), gp100 (a protein included in the maturation of melanosome), Survivin (a protein which involves in the maintenance of apoptosis) of metastatic melanoma patients, MAGE-A1 (a melanoma antigen) and MAGE-A3 (a melanoma antigen) [28]. This evidence concerns the gene TYR and melanoma.