PLN and familial dilated cardiomyopathy: DCM-causing mutations have also been found in the nuclear lamin A/C encoding gene LMNA (4–6%), in the RBM20 gene (2–5%) encoding a nuclear RNA splicing factor, in ion-channel-related genes like SCN5A (2–3%) and PLN, in intercellular junction coding genes such as DSP (3–4%), and in the heat shock Alpha-crystallin B chain coding gene CRYAB [40,41,42,43].