This might enable a directed search for disease-specific cAAb profiles based on the information of abnormally expressed proteins in specific genetic cardiomyopathies, for instance, desmin-positive and CRYAB-R102G-positive protein aggregates in desminopathy [168,169], PLN-positive protein aggregates in PLN p.Arg14del cardiomyopathy [170] and TMEM43-positive protein aggregates in p.S358L TMEM43 ARVC [171]. The gene discussed is TMEM43; the disease is Desminopathy.