Soybean, which is a fundamental supplement of Asian diet, represents an important source of flavonoids, in particular GEN [126], and people in Asia show a lower rate of hormone-dependent cancers, mainly breast and prostate ones [121,127] Indeed, it is known that: (i) GEN can block PSA induction mediated by AR [122,123]; (ii) API, GEN, LUT, NRG, QRC, and RESV can reduce DHT-induced PSA secretion to a different extent in a non-linear manner [56]; (iii) API exerts a protective role against prostate cancer [128]; and, (iv) soy beverage can decrease PSA level in prostate cancer patients [129,130]. This evidence concerns the gene AR and Familial prostate cancer.